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Thames Valley Police emergency crews have reached an incident on the B4477 road linking Carterton and Filkins.
A road closure is in effect between the Carterton junction and the Filkins junction on this route.
Authorities have not given a timeframe for how long this restriction will remain in place and are advising residents to find alternative routes.
The Witney representative, who is at the scene, said the closure is because a member of the public uncovered an unexploded explosive device.
Currently based in Carterton. This concerns Alverscord Road, which had only just reopened and is now closed again following the discovery of an unexploded grenade. Explosive ordnance disposal experts are being summoned. There is hope the road could reopen within roughly two hours, although an exact time has not been confirmed.
