Following approval by the council of governors, Adrian Gardner and Professor Aidan Fowler were appointed to the board of Oxford University Hospitals NHS Foundation Trust.
Both will serve an initial three-year term, beginning on November 1.
Professor Fowler leads patient safety nationally and acts as NHS England’s deputy medical director.
He also holds the deputy chief medical officer position within the Department of Health and Social Care.
The incoming director said he was pleased to join the trust and looked forward to contributing to the continued improvement of services for local residents.
He also expected to draw on national experience of quality and safety while sharing learning from Oxford with provider boards across the NHS.
Mr Gardner brings previous board experience, including service as a non-executive director and audit committee chair.
He previously worked as chief financial officer and chief operating officer in several businesses.
Mr Gardner said his long-standing connection with Oxford had played an important part in his career.
He praised the abilities of the staff and facilities within the OUH hospitals and said he was proud to contribute to the trust’s development during a challenging period for the NHS.
Sir Andrew Morris OBE, chair of OUH, welcomed both appointments.