Oxford United are due to host Reading FC at the Kassam Stadium on Wednesday, November 4, with the League One match scheduled to begin at 7.45pm.
Thames Valley Police has arranged a major policing operation covering the period before, during and after the fixture.
Personnel involved will include football spotters, public-order officers, tactical-cycle specialists, mounted units, police dogs and drones.
A Section 35 dispersal order and Section 60AA powers will be in effect between 11am on Wednesday and 1am on Thursday.
The designated areas extend to parts of Oxford, Didcot and Reading, encompassing the stadium surroundings, Oxford city centre, Didcot Parkway and Reading railway station.
Under Section 35, police officers and PCSOs can order people who are causing, or likely to cause, harassment, alarm or distress to leave the specified area.
Section 60AA gives uniformed officers the authority to require individuals to discard items intended to conceal their identity.
A temporary traffic order also permits the closure of roads surrounding four roundabouts on Grenoble Road during matchdays.
Motorists heading towards the stadium may therefore encounter restrictions.
Officers are cooperating with both football clubs, British Transport Police and other partners to limit disruption.
Supporters have been advised to arrive in good time and follow instructions from stewards and police officers.
Superintendent Jennifer Hogben, who is the tactical commander for the operation, said the fixture was expected to attract considerable interest.
She said the policing arrangements were intended to support a safe visit for everyone attending while preventing anti-social behaviour from affecting others.
Activity would include key transport hubs and the routes used by supporters.
Hogben said violence, disorder, anti-social behaviour and criminality would not be tolerated, with a swift response planned for anyone attempting to cause disruption.
Parents and guardians were advised to establish where their children would be and what they would be doing on the evening of the match.
Police officers said most attendees were expected to come for the football, with personnel available throughout the day to offer reassurance, respond to questions and address any problems.
Enforcement action would be taken where necessary against those engaging in criminal activity.
Concerns could be raised with police officers, stewards or stadium staff on the day.
Reports of criminal behaviour can be made by calling 101, while emergencies should be reported by dialling 999.